Evaluation of statistical techniques to normalize mass spectrometry-based urinary metabolomics data
نویسندگان
چکیده
منابع مشابه
Statistical analysis and modeling of mass spectrometry-based metabolomics data.
Multivariate statistical techniques are used extensively in metabolomics studies, ranging from biomarker selection to model building and validation. Two model independent variable selection techniques, principal component analysis and two sample t-tests are discussed in this chapter, as well as classification and regression models and model related variable selection techniques, including parti...
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A set of data preprocessing algorithms for peak detection and peak list alignment are reported for analysis of liquid chromatography-mass spectrometry (LC-MS)-based metabolomics data. For spectrum deconvolution, peak picking is achieved at the selected ion chromatogram (XIC) level. To estimate and remove the noise in XICs, each XIC is first segmented into several peak groups based on the contin...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical and Biomedical Analysis
سال: 2020
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2019.112854